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Malaria Vaccine

 Plasmodium falciparum antibodies in Ghanaian primigravidae examined

Published in Women's Health Weekly, July 14th, 2005

Investigators have examined the rapid acquisition of isolate-specific antibodies to chondroitin sulfate A-adherent Plasmodium falciparum isolates in Ghanaian primigravidae.

"Recent evidence suggests that pregnancy-associated malaria (PAM), associated with maternal anemia and low birth weight, results from preferential sequestration of parasitized red blood cells (pRBC) in the placenta via binding of variant surface antigens (VSA) expressed on the surface of pRBC to chondroitin sulfate A (CSA). The VSA-mediating CSA binding (VSACSA ) and thus sequestration of pRBC in the placenta are antigenically distinct from those that mediate pRBC sequestration...

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