Breast Cancer
Cadherin expression associated with breast cancer
Published in Women's Health Weekly, July 14th, 2005
"Cadherin cell-cell adhesion proteins are critical for the formation of tissues from single cells. E- and P-cadherin play important roles in the architecture and function of the normal mammary gland," investigators in the United States reported.
"In breast cancers, the expression, or lack there of, of E-cadherin can differentiate tumor types, whereas the misexpression of either P-cadherin or N-cadherin can be a marker of poor prognosis or increased malignancy, respectively," explained K.A. Knudsen and colleagues, Lankenau Institute of Medical Research.
The researchers...
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