Women's Health Weekly
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Carcinogenesis
A region of human chromosome 4 is connected to cervical cancer formation
July 14th, 2005
A region of human chromosome 4 is connected to cervical cancer formation. "Human papillomavirus (HPV) types 16 and 18 are known to play a major role in cervical carcinogenesis. Additional genetic alterations are required for the development and progression of cervical cancer," scientists writing in the journal Genes Chromosomes & Cancer report. "Previously, we showed that the introduction of an entire human chromosome 4 into HPV-immortalized cells by microcell-mediated chromosome transfer (MMCT) can induce senescence in cell hybrids. In the present study, we established eight new murine donor cell lines harboring different fragments of the...
Source: Women's Health Weekly (2005-07-14)
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