Drug Delivery

Estradiol-releasing vaginal ring and tablets equally effective, safe

Published in Women's Health Weekly, July 14th, 2005

Low-dose estradiol administered either by a vaginal ring or by tablets shows equal endometrial safety and efficacy, a study from Australia shows.

E. Weisberg and colleagues at the Sydney Center for Reproductive Health Research conducted a prospective, randomized study to "compare the safety of a continuous low-dose estradiol-releasing vaginal ring (ESTring) to that of a vaginal estradiol tablet (Vagifem) on the endometrium and the relief of subjective symptoms and signs of urogenital estrogen deficiency. Quality of life and acceptability of treatment delivery were also assessed."

According to their report, 185 "women were assigned in a 2:1 ratio to...

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Source: Women's Health Weekly (2005-07-14)

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