Women's Health Weekly
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Breast Cancer
Changes in gene expression associated with response to neoadjuvant chemotherapy
July 21st, 2005
Changes in gene expression might predict the response of breast carcinomas to neoadjuvant chemotherapy. According to recent research published in the Journal of Clinical Oncology, "At present, clinically useful markers predicting response of primary breast carcinomas to either doxorubicin-cyclophosphamide (AC) or doxorubicin-docetaxel (AD) are lacking. We investigated whether gene expression profiles of the primary tumor could be used to predict treatment response to either of those chemotherapy regimens." "Within a single-institution, randomized, phase II trial, patients with locally advanced breast cancer received six courses of either AC...
Source: Women's Health Weekly (2005-07-21)
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