Women's Health Weekly
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Breast Cancer
Exogenous progestins influence gene expression of breast cancer cells
July 21st, 2005
Many mammary tumors express estrogen receptors (ER) and progesterone receptors (PR), and there is increasing evidence that progestins influence gene expression of breast tumor cells. "To analyze the impact of progestins on breast cancer cells," scientists stated that they "compared (a) the expression of two cytokines involved in tumor progression and searched (b) for differentially regulated genes by a microarray containing 2400 genes on T47D breast cancer cells cultured for 6 days with 17 beta-estradiol (E-2) or E-2+medroxyprogesterone acetate (E-2+MPA)." According to investigators, "Lower amounts of PDGF and TNF alpha were found in culture...
Source: Women's Health Weekly (2005-07-21)
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