Women's Health Weekly
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Breast Cancer
LAF-4 aberrantly expressed in human breast cancer
July 21st, 2005
Scientists suggested that LAF-4 was aberrantly expressed in human breast cancer. "LAF-4, which encodes a nuclear protein with transactivation potential, is fused to the MLL gene in acute lymphoblastic leukemia (ALL). We identified LAF-4 as a gene that is transcriptionally deregulated in breast tumors and thus may have a pathological role in mammary tumorigenesis," investigators in Canada reported. "In line with the previous finding that LAF-4 expression is tissue specific, we did not detect any LAF-4 mRNA in normal mammary epithelial cell lines. However, 2 of 5 breast cancer cell lines were found to express LAF-4 at both the RNA and protein levels....
Source: Women's Health Weekly (2005-07-21)
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