Women's Health Weekly
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Breast Cancer Vaccine
Monoclonal antibody shows antitumor activity against breast cancer
July 21st, 2005
A neutralizing anti-fibroblast growth factor 8 monoclonal antibody shows potent antitumor activity against androgen-dependent mouse mammary tumors in vivo. "Fibroblast growth factor 8b (FGF8b) has been implicated in oncogenesis of sex hormone-related malignancies. A murine monoclonal anti-FGF8 antibody, KM1334, has been raised against a FGF8b-derived peptide and shown to neutralize FGF8b activity in an androgen-dependent mouse mammary cell line (SC-3) in vitro growth. The purpose of this study was to evaluate KM1334 as a therapeutic agent for FGF8-dependent cancer. "Specificity and neutralizing activity of KM1334 were examined in vitro. In vivo...
Source: Women's Health Weekly (2005-07-21)
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