Women's Health Weekly
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Breast Cancer
Clinical significance of transcription factors Snail, Slug, and Twist evaluated
July 28th, 2005
The clinical significance of transcription factors Snail, Slug, and Twist was evaluated. According to recent research from Wales, "Slug, Snail, and Twist are transcription factors that regulate the expression of tumor suppressors such as E-cadherin. We examined the distribution and expression of these three molecules together with the methylation of the Twist gene promoter in human breast cancer to elucidate their clinical significance." "Frozen sections from breast cancer primary tumors (tumor, n=114; background, n=30) were immunostained with Slug, Snail, and Twist antibodies. RNA was reverse-transcribed, quantified, and analyzed by quantitative...
Source: Women's Health Weekly (2005-07-28)
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