Women's Health Weekly
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Cancer Vaccine
Endometrial cancer responds to cancer/testis antigen
July 28th, 2005
Women with endometrial cancer frequently had immune responses to a cancer/testis antigen. "Identification of cancer/testis antigens useful for diagnosis or immunotherapy of cancers was attempted by cDNA expression cloning with patients' sera (SEREX). cDNA expression libraries made from testis or endometrial cancer cell lines were screened using sera from patients with endometrial cancer or melanoma patients immunized with dendritic cells pulsed with autologous tumor lysates. Tissue-specific expression by RTPCR and immunogenicity by Western blotting of the bacterial recombinant antigen with sera from cancer patients were evaluated," scientists in Japan report. ...
Source: Women's Health Weekly (2005-07-28)
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