Women's Health Weekly
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Cervical Cancer
HPV capsid mutation allows escape from cervical cancer immunity
July 28th, 2005
A human papillomavirus (HPV) capsid mutation allows the escape from dendritic cell-dependent innate immunity in cervical cancer. "Infection with oncogenic human papillomaviruses (HPVs), typified by HPV type 16 (HPV16), is a necessary cause of cervical cancer. Prophylactic vaccination with HPV16 L1 virus-like particles (VLPs) provides immunity. HPV16 VLPs activate dendritic cells and a potent neutralizing immunoglobulin G (IgG) response, yet many cervical cancer patients fail to generate detectable VLP-specific IgG. "Therefore, we examined the role of the innate recognition of HPV16 L1 in VLP-induced immune responses and its evasion during...
Source: Women's Health Weekly (2005-07-28)
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