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Bacteriology

Secondary inclusions may enable chlamydiae to maintain infection

Investigators at the University of Washington School of Medicine report, "Chlamydiae are obligate intracellular bacteria that occupy a nonacidified vacuole (the inclusion) during their entire developmental cycle. These bacteria produce a set of proteins (Inc proteins) that localize to the surface of the inclusion within infected cells. Chlamydia trachomatis IncA is also commonly found in long fibers that extend away from the inclusion."

Researchers used standard and confocal immunofluorescence microscopy to demonstrate that these fibers extend to newly developed inclusions,...

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