Women's Health Weekly
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Breast Cancer
E-cadherin loss predicts poor outcome in non-lobular carcinomas
August 4th, 2005
Loss of E-cadherin expression predicts poor outcome in breast carcinoma patients with non-lobular tumors. "E-cadherin is a cell adhesion molecule that is expressed in normal breast tissue and is often considered useful as a phenotypic marker in breast cancer diagnosis, with absence of its expression frequently observed in tumors of lobular subtype," pathologists in England explained. "However, the clinicopathological and prognostic value of E-cadherin in the more frequent non-lobular types of breast carcinoma is unclear." In a study conducted by E.A. Rakha and coauthors at the University of Nottingham, "E-cadherin expression was assessed...
Source: Women's Health Weekly (2005-08-04)
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