Women's Health Weekly
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Breast Cancer
FoxM1 depletion causes mitotic catastrophe in tumor cells
August 4th, 2005
Depletion of the forkhead transcription factor FoxM1 triggers mitotic catastrophe in breast cancer cells. FoxM1 expression "correlates with proliferative status in a variety of normal and transformed cell types," oncologists in Massachusetts explained. "Elevated expression of FoxM1 has been noted in both hepatocellular carcinoma and basal cell carcinoma." "However, whether FoxM1 expression is essential for the viability of transformed cells is unknown," noted D.R. Wonsey and colleagues at Wyeth Research in Cambridge. In a recent study, they found that "expression of FoxM1 is significantly elevated in primary breast cancer." ...
Source: Women's Health Weekly (2005-08-04)
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