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Women's Health Weekly

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Breast Cancer



Nuclear heparanase emergence induces mammary cancer cell differentiation



August 4th, 2005

Nuclear heparanase emergence induces mammary cancer cell differentiation.

According to recent research from Japan, "The study of epithelial differentiation touches upon many modern aspects of biology.

"The epithelium is in constant dialogue with the underlying mesenchyme to control stem cell activity, proliferation in transit-amplifying compartments, lineage commitment, terminal differentiation and, ultimately, cell death."

"There are spatially distinct compartments dedicated to each of these events. Recently we reported that heparanase is expressed in nucleus as well as in the cytoplasm and that nuclear heparanase seems to be...


Source: Women's Health Weekly (2005-08-04)

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