Women's Health Weekly
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Breast Cancer
Heat shock protein 90 inhibitor potentiates breast cancer cell bone metastasis
August 11th, 2005
A heat shock protein 90 inhibitor potentiates bone metastasis of breast cancer cells. "Breast cancer metastasis to the bone occurs frequently, causing numerous complications including severe pain, fracture, hypercalcemia, and paralysis. Despite its prevalence and severity, few effective therapies exist," scientists in Australia report. "To address this," said the authors, "we examined whether the heat shock protein 90 (Hsp90) inhibitor, 17-allylamino-17-demethoxygeldanamycin (17-AAG), would be efficacious in inhibiting breast cancer metastasis to bone. "Utilizing the human breast cancer subline, MDA-MB-231SA, previously in vivo...
Source: Women's Health Weekly (2005-08-11)
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