Women's Health Weekly
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Breast Cancer Vaccine
A Tat fusion protein-based tumor vaccine for breast cancer developed
August 11th, 2005
Scientists have developed a Tat fusion protein-based tumor vaccine for breast cancer. A study from the United States recently reported "that dendritic cells (DCs) transduced with a fusion protein between Her2/neu and the protein transduction domain Tat (DC-Tat-extracellular domain [ECD]) induced Her2/neu-specific CD8+ T cells in vitro. This study tested the in vivo efficacy of DC-Tat-ECD in a murine breast cancer model. "FVB/N mice received 1 or 2 weekly intraperitoneal immunizations with syngeneic DC-Tat-ECD followed by a tumor challenge with syngeneic neu+ breast cancer cells, and tumor development was monitored. To test for Her2/neu specificity,...
Source: Women's Health Weekly (2005-08-11)
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