Women's Health Weekly
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Breast Cancer Vaccine
Enhanced immunity by DNA vaccine needed for metastatic breast cancer
August 11th, 2005
Enhanced immunity by NeuEDhsp70 DNA vaccine is needed to combat an aggressive spontaneous metastatic breast cancer. "The rapid growth and ruthless metastasis of tumors demand effective broad immune responses. Dendritic cells (DCs) are critical in developing tumor vaccines. Recent investigations have been focused on modifying tumor antigens to target DCs to induce immune responses efficiently in vivo. In this study, human hsp70 was fused to the extracellular domain of rat Her2/Neu (NeuEDhsp70) for enhancing anti-tumor immunity in aggressive breast tumor models. Neu EDhsp 70-conditioned DCs produced significant IL-12p40 and effectively presented NeuED antigens to T cells...
Source: Women's Health Weekly (2005-08-11)
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