Women's Health Weekly
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Breast Cancer
Medroxyprogesterone empowers the Nm23-H1 metastasis suppressor gene
August 18th, 2005
Medroxyprogesterone empowers the Nm23-H1 metastasis suppressor gene. According to recent research from the United States, "re-establishment of metastasis suppressor gene expression may constitute a therapeutic strategy for high-risk breast cancer patients." "We previously showed that medroxyprogesterone acetate (MPA), a progestin that has been tested as treatment for advanced breast cancer, elevates expression of the Nm23-H1 metastasis suppressor gene in hormone receptor-negative metastatic human breast carcinoma cell lines in vitro via a glucocorticoid receptor-based mechanism," said D. Palmieri and colleagues, U.S. National Institutes of...
Source: Women's Health Weekly (2005-08-18)
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