Women's Health Weekly
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Breast Cancer
Metabolites are investigated as predictors of risk for breast cancer
August 18th, 2005
Metabolites are investigated as predictors of risk for breast cancer. "Estrogen is metabolized in the body through two mutually exclusive pathways yielding metabolites with different biological activities: the low estrogenic 2-hydroxyestrone (2-OHE1) and the highly estrogenic 16 alpha-hydroxyestrone (16 alpha-OHE1). Early evidence has demonstrated that exercise may alter estrogen metabolism to favor the weak estrogen, 2-OHE1. The ratio of these metabolites (2/16) may be predictive of risk for developing breast cancer," investigators in the United States report. "Seventy-seven eumenorrheic females completed physical activity logs for 2 weeks prior to...
Source: Women's Health Weekly (2005-08-18)
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