Women's Health Weekly
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Breast Cancer
The C-terminal region of EF-hand protein facilitates cancer metastasis
August 18th, 2005
The C-terminal region of EF-hand protein facilitates cancer metastasis. "The EF-hand protein, S100A4, binds calcium ions and interacts specifically in vitro with protein targets. Elevated levels of S100A4 have been shown to produce a metastatic phenotype in independent models of breast cancer," scientists writing in the journal Oncogene report. "The presence of S100A4 in the carcinoma cells of patients with different carcinomas is associated with reduced patient survival. In order to identify the region of the S100A4 molecule that is responsible for its metastasis-inducing properties, specific mutant S100A4 genes and proteins have been...
Source: Women's Health Weekly (2005-08-18)
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