Women's Health Weekly
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Gynecology
Cervical cancer metastasis follows heparan sulfate glycosaminoglycan loss
August 18th, 2005
Cervical cancer metastasis follows heparan sulfate glycosaminoglycan loss. "Perlecan is a major heparan sulfate proteoglycan of basement membrane (BM) and binds to various cytokines and growth factors via its heparan sulfate glycosaminoglycan (HS-GAG) chains. The aim of this study was to investigate BM HS-GAG expression in invasive cervical cancers," scientists in Japan report. "We investigated the expression of BM HS-GAG by immunohistochemistry in 143 invasive cervical cancers and 30 metastatic lymph node samples, and analyzed correlations with various clinicopathological features. Furthermore, the gene expression levels of heparanase were assessed...
Source: Women's Health Weekly (2005-08-18)
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