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Women's Health Weekly

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Apoptosis



Fibrin studied, effect on cultured term human trophoblasts revealed



August 25th, 2005

According to a study from the United States, fibrin enhances differentiation, but not apoptosis, and limits hypoxic injury of cultured term human trophoblasts.

"We hypothesized that fibrin enhances apoptosis and modulates differentiation of trophoblasts in vitro," wrote R.G. Humphrey and colleagues, Washington University.

"Cytotrophoblasts isolated from normal term human placentas were cultured {{<=}}72 h in DMEM-10%-FBS on a fibrin matrix in standard or hypoxic conditions. Trophoblasts were cultured on plastic (control), type I collagen (matrix control), or dishes with fibrinogen, fibrin degradation products (FDP), thrombin, plasma fibronectin or...


Source: Women's Health Weekly (2005-08-25)

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