Women's Health Weekly
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Breast Cancer
Kinase-inactive glycogen synthase kinase 3 beta promoted mammary tumorigenesis
August 25th, 2005
Scientists claimed that kinase-inactive glycogen synthase kinase 3 beta (GSK3 beta) promoted Wnt signaling and mammary tumorigenesis. "Recent studies have implicated ectopic activation of the Wnt pathway in many human cancers, including breast cancer. Beta-catenin is a critical coactivator in this signaling pathway and is regulated in a complex fashion by phosphorylation, degradation, and nuclear translocation. GSK3 beta phosphorylation of the NH2-terminal domain of beta-catenin targets it for ubiquitination and proteosomal degradation," researchers in the United States reported. "We hypothesized that expression of kinase-inactive GSK3 beta (KI-GSK3...
Source: Women's Health Weekly (2005-08-25)
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