Women's Health Weekly
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Breast Cancer Vaccine
Polyomavirus VP1/VP2Her2 virus-like particles prevent tumor growth
August 25th, 2005
A single vaccination with polyomavirus VP1/VP2Her2 virus-like particles prevents outgrowth of HER-2/neu-expressing tumors. According to a study from Sweden and Italy, "Murine polyomavirus (MPyV) VP1 virus-like particles (VLPs), containing a fusion protein between MPyV VP2 and the extracellular and transmembrane domain of HER-2/neu (Her2), Her21-683 PyVLPs, were tested for their ability to vaccinate against Her2-expressing tumors in two different in vivo models. Protection was assessed both against a lethal challenge with a BALB/c mammary carcinoma transfected with human Her2 (D2F2/E2) and against the outgrowth of autochthonous, mammary carcinomas in BALB-neuT...
Source: Women's Health Weekly (2005-08-25)
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