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Cardiovascular Research

2-methoxyestradiol exerts renal and CV protective effects

Published in Women's Health Weekly, August 25th, 2005

Estradiol metabolites attenuate renal and cardiovascular injury induced by chronic nitric oxide synthase inhibition.

"Our previous studies in rodent models of nephropathy demonstrate that 2-hydroxyestradiol (2HE), an estradiol metabolite with little estrogenic activity, exerts renoprotective effects. In vivo, 2HE is readily converted to 2-methoxyestradiol (2ME), a major estradiol metabolite with no estrogenic activity," researchers in the United States report.

S.P. Tofovic and colleagues of the University of Pittsburgh wrote, "The goal of [our present] study was to determine whether 2ME has renal and cardiovascular protective effects in vivo."

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