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Cardiovascular Research

2-methoxyestradiol exerts renal and CV protective effects

"Our previous studies in rodent models of nephropathy demonstrate that 2-hydroxyestradiol (2HE), an estradiol metabolite with little estrogenic activity, exerts renoprotective effects. In vivo, 2HE is readily converted to 2-methoxyestradiol (2ME), a major estradiol metabolite with no estrogenic activity," researchers in the United States report.

S.P. Tofovic and colleagues of the University of Pittsburgh wrote, "The goal of [our present] study was to determine whether 2ME has renal and cardiovascular protective effects in vivo."

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