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Women's Health Weekly

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Diagnostics



Xenograft models link genes to breast cancer metastasis



August 25th, 2005

Xenograft models link genes to breast cancer metastasis.

"Metastasis is the primary cause of death from breast cancer. A xenograft model was used to identify genes potentially involved with metastasis, comparing expression in the poorly metastatic GI1O1A human breast cancer cell line and a highly metastatic variant, GILM2," researchers in the United States report.

"cDNA microarray analyses of these isogenic variants were done using 16K Operon 70-mer oligonucleotide microarray slides. Differentially expressed genes were identified by ANOVA, and differences of {{>=}}2.5-fold were found for 106 genes," stated H.M. Kluger and colleagues, University of...


Source: Women's Health Weekly (2005-08-25)

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