Women's Health Weekly
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Endocrinology
Decoy therapy raises estrogen receptor alpha protein in breast cancer cells
August 25th, 2005
Decoy therapy raises estrogen receptor alpha protein in breast cancer cells. "This study addresses the hypothesis that transfection of oligonucleotide mimicking a negative regulatory sequence of promoter C of estrogen receptor alpha (ER alpha) gene is sufficient for its re-expression in ER-negative human cancer cell lines," scientists in Italy report. "Even if the negative transcription regulator subtracted by the transcription factor decoy is not yet been identified, we demonstrated that after this decoy treatment, the cells produced a functional ER alpha protein able to respond to 17-beta-estradiol and to transactivate a transfected estrogen...
Source: Women's Health Weekly (2005-08-25)
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