Women's Health Weekly
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Aging
Premature ovarian aging studied, role of Gpr3 clarified
August 25th, 2005
A study from Belgium has reported on premature ovarian aging in mice deficient for Gpr3. "After becoming competent for resuming meiosis, fully developed mammalian oocytes are maintained arrested in prophase I until ovulation is triggered by the luteotropin surge. Meiotic pause has been shown to depend critically on maintenance of cAMP level in the oocyte and was recently attributed to the constitutive Gs (the heterotrimeric GTP-binding protein that activates adenylyl cyclase) signaling activity of the G protein-coupled receptor GPR3. "Here we show that mice deficient for Gpr3 are unexpectedly fertile but display progressive reduction in litter size...
Source: Women's Health Weekly (2005-08-25)
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