Women's Health Weekly
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Alzheimer Disease
Amyloid-mediated endothelial damage studied, lack of estrogen protection shown
August 25th, 2005
A study from Spain has chronicled the lack of estrogen protection in amyloid-mediated endothelial damage due to protein nitrotyrosination. "Amyloid beta-peptide (Abeta) cytotoxicity, the hallmark of Alzheimer disease, implicates oxidative stress in both neurons and vascular cells, particularly endothelial cells. Consequently, antioxidants have shown neuroprotective activities against Abeta-induced cytotoxicity," wrote M. Coma and colleagues, University of Pompeu Fabra. "Among the different antioxidants used in both in vitro and in vivo studies, 17 beta-oestradiol (E-2) has garnered the most attention. Estrogen attenuated Abeta(E22Q)-induced toxicity...
Source: Women's Health Weekly (2005-08-25)
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