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Anticancer Agents

Anticancer agent for hypoxic cells discovered

In a recent study published in the journal Proceedings of the National Academy of Sciences of the United States of America, researchers in the United States reported, "To target malignant cells residing in hypoxic regions of solid tumors, we have designed and synthesized prodrugs generating the cytotoxic alkylating species 1,2-bis(methylsulfonyl)-1-(2chloroethyl)hydrazine (90CE) after bioreductive activation."

"We postulate that one of these agents, 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)-2-_{-(4-nitrophenyl)ethoxy]carbonyl]hydrazine (KS119), requires enzymatic...}

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