Women's Health Weekly
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Breast Cancer
BMP/SMAD pathway may play role in progression of ER-positive tumors
September 1st, 2005
The BMP/SMAD pathway may be involved in the progression of estrogen receptor-positive breast tumors. "Estrogen receptor expression is generally a sign of better tumor differentiation and comparatively good clinical outcome in invasive breast cancer," oncologists in Germany explained. "However, estrogen receptor-positive, poorly differentiated carcinomas with a poor clinical outcome exist." "The underlying genetic mechanisms and the genes involved remain obscure, even though chromosome 7p gains seem to be associated with these uncommon tumors," noted M.W. Helms and colleagues at the University of Munster. In a recent study, they "compared two subsets...
Source: Women's Health Weekly (2005-09-01)
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