Women's Health Weekly
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Breast Cancer
Diagnostic approaches for determining HER-2 status in breast cancer compared
September 8th, 2005
Scientists compared different diagnostic approaches for determining HER-2 status in breast cancer. According to recent research from France, "HER-2 status is generally determined by immunohistochemistry (IHC) or fluorescence in situ hybridization (FISH). Both methods are only semiquantitative, require a tumor sample, and can be difficult to reproduce." "We compared these methods with two quantitative approaches, one measuring HER-2 gene copy number in tissue by real-time quantitative PCR (qPCR), and the other measuring shed HER-2 protein in serum by ELISA in patients with metastatic disease. We analyzed 52 cases of metastatic breast cancer for which...
Source: Women's Health Weekly (2005-09-08)
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