Women's Health Weekly
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Breast Cancer
Migration-stimulating factor linked to tumor progression
September 8th, 2005
Researchers in France report that migration-stimulating factor is linked to breast cancer tumor progression. According to X. Houard and associates at INSERM Unite 36, "Like most extracellular matrix (ECM) components, fibronectin (Fn) is proteolyzed generating specific activities. Fibronectin proteinase (Fn-proteinase) represents such a cryptic activity located in the gelatin-binding domain (GBD) of Fn and displays a zinc metalloproteinase activity." The researchers explained, "The migration-stimulating factor (MSF) is a truncated Fn isoform generated by alternative mRNA splicing and corresponds to the N-terminal part of Fn that comprises the GBD. We...
Source: Women's Health Weekly (2005-09-08)
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