Women's Health Weekly
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Chemoresistance
Dihydropyridines and pyridines counteracted multidrug resistance
September 8th, 2005
Dihydropyridines and pyridines counteracted the multidrug resistance of breast and lung cancer cells. "Breast cancer resistance protein (BCRP, ABCG2) is a recently identified member of the ATP-binding cassette family of cell surface transport proteins. This study was conducted to investigate the effect of a series of newly synthesized 1,4-dihydropyridines and pyridines, designed as potent P-glycoprotein inhibitors, on BCRP-mediated drug efflux both in vitro and in vivo," scientists in the United States reported. "The effects of 25 synthesized dihydropyridines and corresponding pyridines along with 4 commercially available dihydropyridines...
Source: Women's Health Weekly (2005-09-08)
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