Antiproliferative Activity
Lamprey gonadotropin-releasing hormone III inhibited breast cancer cell growth
Published in Women's Health Weekly, September 8th, 2005
According to a study from the United States, "Naturally occurring isoforms of GnRH share residues 1-4 and 9-10. lGnRH-III, the third isoform isolated in the sea lamprey, has no endocrine effect in mammals but shows a direct antiproliferative effect on human breast, prostate and endometrial cancer cell lines. To investigate these features, residues 5-8 of lGnRH-III were systematically replaced with Ala."
"The ability of the synthetic analogs to interact with receptors on MDA-MB 231 human breast cancer cells and their effect on the growth of the same cell...
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