Women's Health Weekly
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Breast Cancer
AmpArray profiled expression of ABC transporters in a drug-resistant cell line
September 8th, 2005
AmpArray was used to profile the expression of ATP-binding cassette (ABC) transporters in a drug-resistant breast cancer cell line. According to recent research from the United States, "ABC membrane proteins comprise a superfamily of transporters with a wide variety of substrates. Humans have 49 members in this superfamily." "Several human ABC transporters, such as ABCB1 and ABCC1, have been attributed to cause multidrug resistance (MDR) in cancer treatment when over-expressed. In the past, an MDR cancer cell line MCF7/AdVp3000 has been selected, and overexpression of ABCG2 was thought to cause MDR in this cell line. However, ectopic overexpression...
Source: Women's Health Weekly (2005-09-08)
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