Therapeutic Target
Structure, mechanism, and physiologic role of arginase in sexual arousal studied
Published in Women's Health Weekly, September 22nd, 2005
According to a study from the University of Pennsylvania,mammalian arginases I and II require an intact binuclear manganese cluster for the hydrolysis of L-arginine to generate L-ornithine and urea. Although arginase isozymes differ in terms of their tissue distribution, cellular localization, and metabolic function, each employs a metal-activated hydroxide mechanism for catalysis."
"To date, the best arginase inhibitors are those bearing N-hydroxyguanidinium or boronic acid "warheads" that can bridge the binuclear manganese...
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