Women's Health Weekly
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Breast Cancer
FoxA1 regulates estrogen receptor binding in tumor cells
September 22nd, 2005
The forkhead protein FoxA1 plays a key role in mediating breast tumor cell estrogen responses. "Estrogen plays an essential physiologic role in reproduction and a pathologic one in breast cancer," oncologists in Boston explained. "The completion of the human genome has allowed the identification of the expressed regions of protein-coding genes; however, little is known concerning the organization of their cis-regulatory elements." In their study, J.S. Carroll and colleagues at the Harvard University Dana-Farber Cancer Institute "mapped the association of the estrogen receptor (ER) with the complete nonrepetitive sequence of human chromosomes 21 and...
Source: Women's Health Weekly (2005-09-22)
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