Women's Health Weekly
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Breast Carcinoma
Undifferentiated-type breast carcinomas identified by KIT/EGFR overexpressions
September 22nd, 2005
Undifferentiated-type breast carcinomas can be identified by KIT and/or epidermal growth factor receptor overexpression. Researchers hypothesized that "four histopathological types or subtypes of breast carcinoma were undifferentiated types characterized by bidirectional differentiation toward both luminal epithelial and myoepithelial cells and had characteristic molecular changes: invasive ductal carcinoma (IDC) with a large central acellular zone, atypical medullary carcinoma (a subgroup in Grade 3 solid-tubular carcinoma), matrix-producing carcinoma, and spindle-cell carcinoma (or carcinoma with spindle-cell metaplasia)." "In 32 cases of the...
Source: Women's Health Weekly (2005-09-22)
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