Women's Health Weekly
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Cervical Cancer
G-308A TNF-alpha polymorphism associated with increased risk of cervical cancer
September 22nd, 2005
G-308A tumor necrosis factor-alpha (TNF-alpha) polymorphism was associated with an increased risk of invasive cervical cancer. "Cervical cancer is initiated by high-risk human papillomaviruses (HPV-16 and HPV-18), but an effective immune response may control the progression of this disease. TNF-alpha is a pro-inflammatory cytokine, that has been implicated in several cancers," scientists in Portugal reported. "In a case-control study, we evaluated the association between the G-308A TNF-alpha promoter polymorphism and the risk for invasive cervical cancer (ICC). TNF-alpha polymorphism was analyzed by PCR-RFLP and confirmed by sequencing. DNA was...
Source: Women's Health Weekly (2005-09-22)
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