Contraception
Antiangiogenic agents disrupt periovulatory events in monkeys
Published in Women's Health Weekly, September 22nd, 2005
"To determine if antiangiogenic agents disrupt primate ovarian function, vehicle or a general angiostatic compound (TNP-470), specific antagonists of vascular endothelial growth factor (soluble VEGF receptor-1, sVEGFR-1; anti-VEGF monoclonal antibody, VEGF Ab) and/or an angiopoietin antagonist (Ang-2) were administered to rhesus monkeys: locally via injection into the preovulatory follicle at midcycle or the developing corpus luteum at the midluteal phase; or systemically via subcutaneous injection in the early follicular phase or at midcycle during the natural menstrual cycle," scientists in the United...
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