Women's Health Weekly
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Breast Cancer
Integrin alpha6beta4 promotes expression of autotaxin in breast carcinoma
September 29th, 2005
Integrin alpha6beta4 promotes expression of autocrine motility factor autotaxin in breast carcinoma cells. "In advanced breast carcinomas, the alpha6beta4 integrin is associated with a migratory and invasive phenotype. In our current study, we show that expression of the alpha6beta4 integrin in MDA-MB-435 breast carcinoma cells leads to increased expression of the autocrine motility factor autotaxin, as determined by Affymetrix gene chip, realtime quantitative RT-PCR and immunoblot analyses," scientists in Texas published recently in Oncogene. "We further demonstrate that increased autotaxin secretion from integrin alpha6beta4 expressing cells...
Source: Women's Health Weekly (2005-09-29)
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