Women's Health Weekly
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Breast Cancer
Mammary tumor growth inhibited by novel nontoxic retinoid
September 29th, 2005
Mammary tumor growth was inhibited by a novel nontoxic retinoid. "Previous studies from our laboratory suggest that 4-HPROG, the O-glucuronide derivative of 4-HPR, has improved mammary cancer chemopreventive/ antitumor activities as well as reduced toxicity, as compared to 4-HPR. This O-linked glucuronide derivative is a substrate to the beta-glueuronidase enzyme and may also undergo hydrolysis in vivo to the vitamin A metabolite, retinoic acid, that is toxic at high concentrations," scientists in the United States reported. "In an effort to improve analog potency relative to its toxicity, the 4-HPROG's phenolic oxygen was replaced with a methylene...
Source: Women's Health Weekly (2005-09-29)
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