Women's Health Weekly
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Breast Cancer
P-glycoprotein inhibited by natural products in human breast cancer cells
September 29th, 2005
Natural products in human breast cancer cells inhibited p-glycoprotein (P-gp). "Multidrug resistance (MDR) is one of the most significant obstacles in cancer chemotherapy. One of the mechanisms involved in the development of MDR is the over-expression of P-gp," investigators in South Korea reported. "It is widely known that natural compounds found in vegetables, fruits, plant-derived beverages and herbal dietary supplements not only have anticancer properties, but may also modulate P-gp activity. Therefore, the purpose of this investigation was to examine the effects of naturally occurring products on P-gp function in human breast cancer cell lines,...
Source: Women's Health Weekly (2005-09-29)
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