Women's Health Weekly
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Breast Cancer
Relationship of sulfotransferase1A1 to postmenopausal breast cancer examined
September 29th, 2005
The possible relationship of sulfotransferase1A1 to postmenopausal breast cancer was recently examined. According to a study from Sweden, "The detoxification enzyme sulfotransferase1A1 (SULT1A1) is implicated in the inactivation of estrogens and the activation of promutagens and procarcinogens. SULT1A1 activity varies among individuals, and this difference in phenotype is, in part, controlled by genetic polymorphism (Arg -->His in codon 213)." "It is hypothesized that the His allele contributes to the risk of postmenopausal breast cancer," wrote P. L. Jerevall and colleagues. "Frequencies of the Arg/His alleles were estimated in 229 postmenopausal...
Source: Women's Health Weekly (2005-09-29)
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