Women's Health Weekly
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Breast Cancer Vaccine Development
Dendritic cell vaccine stimulates mammaglobin-specific T cells
September 29th, 2005
Tat mammaglobin fusion protein-transduced dendritic cells stimulate mammaglobin-specific CD4 and CD8 T cells. According to recent research published in the journal Breast Cancer Research And Treatment, "Proteins can be efficiently introduced into cells when fused to a protein transduction domain, such as Tat from the human immunodeficiency virus. We recently reported that dendritic cells transduced with a Tat fusion protein containing the extracellular domain of Her2/neu (Tat-Her2/neu) induced CD8 cytotoxic T lymphocytes (CTL) that specifically lysed Her2/neu-expressing breast and ovarian cancer cells." "In the current study we further...
Source: Women's Health Weekly (2005-09-29)
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