Women's Health Weekly
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Breast Cancer Vaccine Development
Monoclonal antibody shows potent antitumor activity in breast cancer
September 29th, 2005
A neutralizing anti-fibroblast growth factor 8 monoclonal antibody shows potent antitumor activity against androgen-dependent mouse mammary tumors in vivo. According to recent research from Japan, "Fibroblast growth factor 8b (FGF8b) has been implicated in oncogenesis of sex hormone-related malignancies. A murine monoclonal anti-FGF8 antibody, KM1334, has been raised against an FGF8b-derived peptide and shown to neutralize FGF8b activity in an androgen-dependent mouse mammary cell line (SC-3) in vitro growth. The purpose of this study was to evaluate KM1334 as a therapeutic agent for FGF8-dependent cancer." "Specificity and neutralizing activity of...
Source: Women's Health Weekly (2005-09-29)
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