Women's Health Weekly
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Cancer Therapy
Bcl-xL and c-FLIP genes affected chemosensitivity of MCF-7 breast cancer cells
September 29th, 2005
Scientists suggested that the anti-apoptotic genes Bcl-xL and c-FLIP affected the chemosensitivity of MCF-7 breast cancer cells. According to recent research from the United States, "Intrinsic or acquired resistance to chemotherapy is a major clinical problem leading to the fatality of patients with advanced and metastatic breast cancer. The overexpression of anti-apoptotic genes is believed to play a role in the resistance to chemotherapy." "In the present study, we tested the sensitivity of MCF-7 breast cancer cells overexpressing anti-apoptotic genes TRAF-1, c-FLIP, Bcl-xL, cIAP-2 or Mn-SOD to paclitaxel and docetaxel MTT and trypan blue dye...
Source: Women's Health Weekly (2005-09-29)
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