Women's Health Weekly
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Body Composition
Proopiomelanocortin variants linked to leptin and body fat in women
September 29th, 2005
Proopiomelanocortin gene variants are associated with serum leptin and body fat in a normal female population. According to a study from England and the United States, "A major quantitative trait locus (QTL) determining leptin levels has been linked to the proopiomelanocortin (POMC) region on chromosome 2. Most studies, based on under 350 lean or obese subjects, have shown no association between POMC SNP 8246 C/T and serum leptin, but significant associations have been reported with RsaI 8246 C/T SNP haplotypes." "We have investigated association of four POMC SNPs with body composition and serum leptin in 2,758 normal Caucasian female subjects (mean...
Source: Women's Health Weekly (2005-09-29)
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